Author/Authors :
Chia، نويسنده , , Wai Kit and Sharifah، نويسنده , , Noor Akmal and Reena، نويسنده , , Rahayu Md Zin and Zubaidah، نويسنده , , Zakaria and Clarence-Ko، نويسنده , , Ching Huat and Rohaizak، نويسنده , , Muhammad and Naqiyah، نويسنده , , Ibrahim and Srijit، نويسنده , , Das and Hisham، نويسنده , , Abdullah Nor and Asmiati، نويسنده , , Arbi and Rafie، نويسنده , , Md Kaslan، نويسنده ,
Abstract :
At the present time, the differentiation between follicular thyroid carcinoma (FTC) and adenoma can be made only postoperatively and is based on the presence of capsular or vascular invasion. The ability to differentiate preoperatively between the malignant and benign forms of follicular thyroid tumors assumes greater importance in any clinical setting. The PAX8-PPARG translocation has been reported to occur in the majority of FTC. In this study, a group of 60 follicular thyroid neoplasms [18 FTC, 1 Hurthle cell carcinoma (HCC), 24 follicular thyroid adenomas (FTA), 5 Hurthle cell adenomas (HCA), and 12 follicular variants of papillary thyroid carcinomas (FV-PTC)] were analyzed to determine the prevalence of the PAX8-PPARG translocation by fluorescence in situ hybridization. The PAX8-PPARG translocation was detected in 2/18 FTC (11.1%). In addition, 2/18 (11.1%) FTC and 1/5 (20%) HCA showed 3p25 aneusomy only. The frequency of the translocation detected in the study was lower compared to the earlier studies conducted in Western countries. This might be attributed to the ethnic background and geographic location. Detection of either the PAX8-PPARG translocation or the 3p25 aneusomy in FTC indicates that these are independent genetic events. It is hereby concluded that 3p25 aneusomy or PAX8-PPARG translocation may play an important role in the molecular pathogenesis of follicular thyroid tumors.
