Title of article
Fusion of HMGA1 to the LPP/TPRG1 intergenic region in a lipoma identified by mapping paraffin-embedded tissues
Author/Authors
Wang، نويسنده , , Xiaoke and Zamolyi، نويسنده , , Renata Q. and Zhang، نويسنده , , Hongying and Pannain، نويسنده , , Vera L. and Medeiros، نويسنده , , Fabiola and Erickson-Johnson، نويسنده , , Michele and Jenkins، نويسنده , , Robert B. and Oliveira، نويسنده , , Andre M.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
4
From page
64
To page
67
Abstract
Ordinary lipoma frequently harbors rearrangement of HMGA2. LPP is the most common partner gene to HMGA2, but has not been seen fused to HMGA1. We report the fusion of HMGA1 to the intergenic region between LPP and TPRG1 in a lipoma. Conventional cytogenetic analysis of an abdominal-wall lipoma diagnosed in a 60-year-old woman showed a t(3;6)(q27;p21). Molecular cytogenetic mapping of available paraffin-embedded tissues revealed the fusion of HMGA1 to a 139-kb genomic region between the LPP and TPRG1 loci. No rearrangement of HMGA2 was found. The biological function of this novel fusion could be similar to the role of HMGA2–LPP in tumorigenesis.
Journal title
Cancer Genetics and Cytogenetics
Serial Year
2010
Journal title
Cancer Genetics and Cytogenetics
Record number
1830136
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