MRI visualization of proteoglycan depletion in articular cartilage via intravenous administration of Gd-DTPA

The effect of intravenous administration of gadolinium diethylenetriamine-pentaacetic acid (Gd-DTPA) on MR images was studied in vitro, using pathologic osteochondral specimens removed during surgery for total endoprosthesis, and in vivo, on a group of volunteers. In ex vivo specimens, lesions of different shape having lower T1 were detected which corresponded to areas with depleted proteoglycans found histologically. In vivo experiments on young volunteers showed that the time course of cartilage enhancement was different for different anatomies. The time for maximum enhancement ranged from 45 min for the ventral femoral condyle to 270 min for patellar cartilage.