Author/Authors :
Kim، نويسنده , , Min Jin and Yoon، نويسنده , , Hoi Soo and Lim، نويسنده , , Gayoung and Kim، نويسنده , , So Young and Lee، نويسنده , , Hee Joo and Suh، نويسنده , , Jintae and Lee، نويسنده , , Juhie and Lee، نويسنده , , Woo-In and Park، نويسنده , , Tae Sung، نويسنده ,
Abstract :
Entire ABL1 gene deletion without BCR/ABL1 rearrangement is a rare phenomenon, with only four cases previously reported. Here we describe a fifth case of ABL1 deletion without BCR/ABL1 rearrangement in an adolescent patient with precursor B-cell lymphoblastic leukemia (B-ALL) and review the relevant literature. It is not clear how ABL1 deletion affects leukemogenesis; however, it is plausible that ABL1 deletion without BCR/ABL1 rearrangement is a rare but recurrent genetic abnormality in precursor B-ALL patients. Further studies are needed to evaluate the extent of the submicroscopic defects in chromosome 9 including ABL1 gene deletion, as well as treatment response and prognosis in long-term follow-up of such patients.
