Characterization of the calcaneal fat pad in diabetic and non-diabetic patients using magnetic resonance imaging

It is well known that diabetic patients have a high incidence of foot ulceration. The purpose of this study was to determine whether magnetic resonance (MR) imaging can detect changes in the composition of the calcaneal fat pad in diabetic feet. MR data were collected in vitro from amputated specimens (eight from diabetic patients and eight from non-diabetic patients) as well as in vivo from age-matched diabetic and control subjects (four subjects each group.) Three types of images were acquired: spin lattice (T1), spin-spin (T2), and magnetization transfer (MT). The in vitro results showed statistically significant differences in the T1, T2, and MT parameters between the two disease groups. The same trends were shown in the study of live subjects but the differences were not statistically significant. The differences are believed to arise from changes in the composition of the tissues as a result of the progression of diabetes.