Author/Authors :
Bang، نويسنده , , Soo-Mee and Seo، نويسنده , , Ji-Weon and Park، نويسنده , , Kyung Un and Kim، نويسنده , , Seok Jin and Kim، نويسنده , , Kihyun and Kim، نويسنده , , Sun-Hee and Cho، نويسنده , , Sung Ran and Kim، نويسنده , , Hugh C. and Song، نويسنده , , Jaewoo and Kim، نويسنده , , Jin Seok and Kim، نويسنده , , Kyung Hee and Lee، نويسنده , , Jae Hoon and Lee، نويسنده , , Je-Jung and Shin، نويسنده , , Myung Geun and Suh، نويسنده ,
Abstract :
To compare the molecular cytogenetic characteristics between Waldenstrِm macroglobulinemia (WM) and multiple myeloma (MM), we performed interphase fluorescent in situ hybridization (FISH) in Korean patients with WM and MM. Forty patients with WM and 132 patients with MM were enrolled onto the study. FISH was performed with seven different probes: 6q21, 6q23, CEP4, CEP9, immunoglobulin (IgH) breakapart, RB1 gene, and 1q25. Out of 22 WM patients, 4 (18%) had abnormal karyotypes, mainly structural changes on conventional karyotyping. After performing FISH for the available 29 cases, deletions of 6q23 and 6q21 were newly detected in 3 cases (10%). There was no other anomaly, including trisomy 4 in WM. No 6q deletion was observed in MM patients, but RB1 deletion was the most common change (45%), followed by IgH translocation (42%) and gain of 1q (38%). In conclusion, Korean WM patients had a low rate of 6q deletion (10%) and no trisomy 4.
