Author/Authors :
Henry، نويسنده , , Pierre-Gilles and Adriany، نويسنده , , Gregor and Deelchand، نويسنده , , Dinesh and Gruetter، نويسنده , , Rolf and Marjanska، نويسنده , , Malgorzata and ?z، نويسنده , , Gülin and Seaquist، نويسنده , , Elizabeth R. and Shestov، نويسنده , , Alexander and U?urbil، نويسنده , , Kâmil، نويسنده ,
Abstract :
In vivo 13C NMR spectroscopy has the unique capability to measure metabolic fluxes noninvasively in the brain. Quantitative measurements of metabolic fluxes require analysis of the 13C labeling time courses obtained experimentally with a metabolic model. The present work reviews the ingredients necessary for a dynamic metabolic modeling study, with particular emphasis on practical issues.
Keywords :
Glutamatergic neurotransmission , TCA cycle , compartmentation , 13C NMR spectroscopy , Metabolic modeling
