Author/Authors :
Anderson، نويسنده , , Adam W. and Heptulla، نويسنده , , Rubina A. and Driesen، نويسنده , , Naomi and Flanagan، نويسنده , , Daniel and Goldberg، نويسنده , , Philip A. and Jones، نويسنده , , Timothy W. and Rife، نويسنده , , Fran and Sarofin، نويسنده , , Hedy and Tamborlane، نويسنده , , William B. Sherwin، نويسنده , , Robert and Gore، نويسنده , , John C.، نويسنده ,
Abstract :
Functional magnetic resonance imaging (fMRI) was used to measure the effects of acute hypoglycemia caused by passive sensory stimulation on brain activation. Visual stimulation was used to generate blood-oxygen-level-dependent (BOLD) contrast, which was monitored during hyperinsulinemic hypoglycemic and euglycemic clamp studies. Hypoglycemia (50±1 mg glucose/dl) decreased the fMRI signal relative to euglycemia in 10 healthy human subjects: the fractional signal change was reduced by 28±12% (P<.05). These changes were reversed when euglycemia was restored. These data provide a basis of comparison for studies that quantify hypoglycemia-related changes in fMRI activity during cognitive tasks based on visual stimuli and demonstrate that variations in blood glucose levels may modulate BOLD signals in the healthy brain.
Keywords :
Hypoglycemia , Functional MRI , Bold effect , Visual Cortex
