Author/Authors :
Wang، نويسنده , , Zhiyue J. and Fischer، نويسنده , , Roland and Chu، نويسنده , , Zili and Mahoney Jr.، نويسنده , , Donald H. and Mueller، نويسنده , , Brigitta U. and Muthupillai، نويسنده , , Raja and James، نويسنده , , Ellen B. and Krishnamurthy، نويسنده , , Rajesh and Chung، نويسنده , , Taylor and Padua، نويسنده , , Eric and Vichinsky، نويسنده , , Elliott and Harmatz، نويسنده , , Paul، نويسنده ,
Abstract :
A magnetic resonance imaging cardiac magnetic susceptometry (MRI-CS) technique for assessing cardiac tissue iron concentration based on phase mapping was developed. Normal control subjects (n=9) and thalassemia patients (n=13) receiving long-term blood transfusion therapy underwent MRI-CS and MRI measurements of the cardiac relaxation rate R2*. Using MRI-CS, subepicardium and subendocardium iron concentrations were quantified exploiting the hemosiderin/ferritin iron specific magnetic susceptibility. The average of subepicardium and subendocardium iron concentrations and R2* of the septum were found to be strongly correlated (r=0.96, P<.0001), and linear regression analysis yielded CIC (μg Fe/gwet tissue)=(6.4±0.4)·R2* septum (s−1) − (120±40). The results demonstrated that septal R2* indeed measures cardiac iron level.
Keywords :
heart , thalassemia , Iron Overload , R2* , MRI , magnetic susceptibility
