Title of article :
Can preoperative diffusion-weighted MRI predict postoperative hepatic insufficiency after curative resection of HBV-related hepatocellular carcinoma? A pilot study
Author/Authors :
Kim، نويسنده , , Seung Up and Kim، نويسنده , , Young-Chul and Choi، نويسنده , , Ji Soo and Kim، نويسنده , , Kyung Sik and Choi، نويسنده , , Gi Hong and Choi، نويسنده , , Jin Sub and Park، نويسنده , , Jun-Yong and Kim، نويسنده , , Do Young and Ahn، نويسنده , , Sang Hoon and Choi، نويسنده , , Eun-Hee and Park، نويسنده , , Young Nyun and Chon، نويسنده , , Chae Yoon and Han، نويسنده , , Kwang-Hyub and Kim، نويسنده , , Myeong-Jin، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2010
Pages :
10
From page :
802
To page :
811
Abstract :
Liver fibrosis determines the functional liver reserve. Several studies have reported that the apparent diffusion coefficient (ADC) values of diffusion-weighted magnetic resonance imaging (DW-MRI) can assess liver fibrosis. We investigated whether DW-MRI predicts postoperative hepatic insufficiency and liver fibrosis in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Twenty-six patients with HBV-related HCC who received preoperative DW-MRI on a 3-T MRI system were enrolled between July and December 2008. ADC values were measured twice by two observers. Three “b values” were used: 50, 400 and 800 s/mm2. Postoperative hepatic insufficiency was defined as persistent hyperbilirubinemia (total bilirubin level >5 mg/dl for more than 5 days after surgery) or postoperative death without other causes. The mean age (21 men and 5 women) was 51.4 years. Three patients experienced postoperative hepatic insufficiency. liver stiffness measurement predicted postoperative hepatic insufficiency, advanced fibrosis (F3–4), and cirrhosis significantly [area under the receiving operator characteristic curve (AUROC)=0.942, 0.771 and 0.818, respectively, with P=.047, 0.048 and 0.006, respectively]; ADC values of DW-MRI, however, did not (AUROC=0.797, 0.648 and 0.491, respectively, with P=.100, 0.313 and 0.938, respectively). Reliability of ADC values between right and left hepatic lobes (ρ=0.868 and ρ=0.910 in the first and second measures of Observer A; ρ=0.865 and ρ=0.831 in the first and second measures of Observer B) was high and the intra- and interobserver reliability (ρ=0.958 in observer A and ρ=0.977 in observer B; ρ=0.929 in the first measure and ρ=0.978 in the second measure between the two observers) were high. All reliability was significant (P<.001). Our results suggest that DW-MRI on a 3-T MRI system is not suitable for predicting postoperative hepatic insufficiency, advanced liver fibrosis, and cirrhosis in patients with HBV-related HCC, despite significantly high reliability.
Keywords :
Chronic hepatitis B , Fibrosis , Diffusion-weighted magnetic resonance imaging , Transient elastography , Liver stiffness measurement , hepatectomy , hepatocellular carcinoma , Apparent diffusion coefficient , Cirrhosis , hepatitis B virus
Journal title :
Magnetic Resonance Imaging
Serial Year :
2010
Journal title :
Magnetic Resonance Imaging
Record number :
1833018
Link To Document :
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