Title of article :
Responses of dopaminergic, serotonergic and noradrenergic networks to acute levo-tetrahydropalmatine administration in naïve rats detected at 9.4 T
Author/Authors :
Liu، نويسنده , , Xiping and Yang، نويسنده , , Zheng and Li، نويسنده , , Rupeng and Xie، نويسنده , , Jun and Yin، نويسنده , , Qian and Bloom، نويسنده , , Alan S. and Li، نويسنده , , Shi-Jiang، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2012
Abstract :
Aim
m of this study was to understand the neuropharmacological characteristics of levo-tetrahydropalmatine (l-THP), a recently found potential treatment for drug addiction, and discover its neural correlates and sites of action.
s
ield pharmacological magnetic resonance imaging (phMRI) was used to detect activation induced by acute l-THP administration in the naïve rat brain at dose levels of 5, 10, 20 and 40 mg/kg.
s
stingly, the pharmacological profile of l-THP selectively binds to the receptors of the dopaminergic, serotonergic and noradrenergic systems. Using the phMRI method, it was demonstrated that l-THP selectively activated the key brain regions of the dopaminergic, serotonergic and noradrenergic systems in a dose-dependent manner.
sion
us studies suggest a critical role of monoamines in the behavioral, pharmacological and addictive properties of psychostimulants. It is suggested that l-THP holds great potential to be a therapeutic medication for drug addiction.
Keywords :
Levo-tetrahydropalmatine , MRI , Bold , Pharmacological connectivity
Journal title :
Magnetic Resonance Imaging
Journal title :
Magnetic Resonance Imaging