Title of article
Epigenetic targeting in pancreatic cancer
Author/Authors
van Kampen، نويسنده , , Jasmijn G.M. and Marijnissen-van Zanten، نويسنده , , Monica A.J. and Simmer، نويسنده , , Femke and van der Graaf، نويسنده , , Winette T.A. and Ligtenberg، نويسنده , , Marjolijn J.L. and Nagtegaal، نويسنده , , Iris D.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2014
Pages
9
From page
656
To page
664
Abstract
The prognosis of pancreatic cancer patients is very poor, with a 5-year survival of less than 6%. Therefore, there is an urgent need for new therapeutic options in pancreatic cancer. In the past years it became evident that deregulation of epigenetic mechanisms plays an important role in pancreatic carcinogenesis. This review focuses on the exploitation of drugs that alter histone modifications, DNA methylation and microRNA expression as options for the treatment of pancreatic cancer.
Keywords
Epigenetics , pancreatic cancer , Histone methyltransferase inhibitor , DNA methyltransferase inhibitor , Histone deacetylase inhibitor , MicroRNA , Therapy
Journal title
Cancer Treatment Reviews
Serial Year
2014
Journal title
Cancer Treatment Reviews
Record number
1836374
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