Title of article
A rapid and convenient synthesis of novel 1-imino-2,3-dihydro-1H-pyrazino[2,1,-b]quinazolin-5-ones
Author/Authors
Pereira، نويسنده , , Maria de Fatima and René Alexandre، نويسنده , , François and Thiéry، نويسنده , , Valérie and Besson، نويسنده , , Thierry، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
3
From page
3097
To page
3099
Abstract
Exploring original approaches for the synthesis of therapeutic agents having a quinazoline part, we discovered that novel 3,4-dihydro-2H-pyrazino[2,1,-b]quinazolines (3) may be rapidly and easily obtained via the chemistry of 4,5-dichloro-1,2,3-dithiazolium chloride (1). Our synthetic approach of this reaction is described with the aim of obtaining a well-controlled access to this very rarely described pyrazino[2,1,-b]quinazoline skeleton.
Keywords
2 , 3-dithiazolium chloride , 5-Dichloro-1 , 4 , 1 , -b]quinazolines , 1 , -b]quinazolin-5-ones , Anthranilate derivatives , quinazolin-4-ones
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1841270
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