Title of article
A synthesis of camptothecin
Author/Authors
Chavan، نويسنده , , Subhash P. and Sivappa، نويسنده , , Rasapalli Sivappa، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
3
From page
3113
To page
3115
Abstract
A total synthesis of camptothecin has been carried out. Central to our synthesis is the intramolecular condensation of a suitably designed ketol, which in turn was obtained from a tricyclic ABC ring synthon. A tandem reductive amination and Michael addition sequence on an unsaturated quinoline ester was employed for the assembly of the ABC skeleton.
Keywords
camptothecin , total synthesis , Tandem reductive amination–Michael addition , Ketol
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1841276
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