Title of article :
A rapid catalytic asymmetric synthesis of 1,3,4-trisubstituted pyrrolidines
Author/Authors :
Belyk، نويسنده , , Kevin M. and Beguin، نويسنده , , Charlotte D. and Palucki، نويسنده , , Michael and Grinberg، نويسنده , , Nelu and DaSilva، نويسنده , , Jimmy and Askin، نويسنده , , David and Yasuda، نويسنده , , Nobuyoshi، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Abstract :
The asymmetric synthesis of 1,3,4-trisubstituted pyrrolidines was accomplished in two steps from readily available starting materials. A 1,3-dipolar cycloaddition of an azomethine ylide to a propiolate ester followed by a Rh-catalyzed asymmetric 1,4-arylation of the resulting pyrroline with an arylboronic acid provided the desired 1,3,4-trisubstituted pyrrolidine products in good to excellent enantioselectivities.
Keywords :
4-addition , Asymmetric 1 , 1 , pyrrolidine , Arylboronic acid , Rhodium-catalyzed , 3-dipolar cycloaddition
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
