Title of article
A total synthesis of verbenachalcone, a bioactive diaryl ether from Verbena littoralis
Author/Authors
Tanabe، نويسنده , , Takamasa and Doi، نويسنده , , Fuminao and Ogamino، نويسنده , , Takahisa and Nishiyama، نويسنده , , Shigeru، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
3477
To page
3480
Abstract
Verbenachalcone 1, isolated from the aerial part of Verbena littoralis H. B. K. (Verbenaceae), has successfully been synthesized by employing anodic oxidation of the phenol derivative 3, as the key step. The bromine and chlorine substituents of 3 effected regioselective introduction of a methoxy group, as well as modulating the oxidation reaction. A flow-cell type apparatus of anodic oxidation provided the desired diaryl ether 4 in good yield.
Keywords
Anodic oxidation , Verbena littoralis H. B. K. , Verbenachalcone , PC12D cells , diaryl ether
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1841419
Link To Document