Title of article
Application of substituted 2-(trimethylsilyl)ethyl esters to suppress diketopiperazine formation
Author/Authors
Borsuk، نويسنده , , Katarzyna and van Delft، نويسنده , , Floris L and Eggen، نويسنده , , Ivo F and ten Kortenaar، نويسنده , , Paul B.W and Petersen، نويسنده , , Annet and Rutjes، نويسنده , , Floris P.J.T، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
3585
To page
3588
Abstract
The use of differently substituted 2-(trimethylsilyl)ethyl esters for C-terminal protection in peptide synthesis has been investigated. While the use of the unsubstituted 2-(trimethylsilyl)ethyl ester resulted in a substantial amount of diketopiperazine at the dipeptide stage, use of the corresponding methyl-substituted silyl ester gave a significant reduction of this undesired pathway. Both esters could be deprotected by fluoride-induced cleavage under mild conditions.
Keywords
Solution phase peptide synthesis , protecting groups , Diketopiperazine formation
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1841454
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