Author/Authors :
Borsuk، نويسنده , , Katarzyna and van Delft، نويسنده , , Floris L and Eggen، نويسنده , , Ivo F and ten Kortenaar، نويسنده , , Paul B.W and Petersen، نويسنده , , Annet and Rutjes، نويسنده , , Floris P.J.T، نويسنده ,
Abstract :
The use of differently substituted 2-(trimethylsilyl)ethyl esters for C-terminal protection in peptide synthesis has been investigated. While the use of the unsubstituted 2-(trimethylsilyl)ethyl ester resulted in a substantial amount of diketopiperazine at the dipeptide stage, use of the corresponding methyl-substituted silyl ester gave a significant reduction of this undesired pathway. Both esters could be deprotected by fluoride-induced cleavage under mild conditions.
