Title of article
Efficient synthesis of N-benzyl-3-aminopyrrolidine-2,5-dione and N-benzyl-3-aminopyrrolidin-2-one
Author/Authors
Vo-Hoang، نويسنده , , Yen and Gasse، نويسنده , , Cécile and Vidal، نويسنده , , Michel and Garbay، نويسنده , , Christiane and Galons، نويسنده , , Hervé، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
3
From page
3603
To page
3605
Abstract
Reaction of N-tert-butyloxycarbonylasparagine (Boc-Asn) with 2 equiv of benzyl bromide in presence of cesium carbonate led to N-benzyl-3-Boc-amino-pyrrolidin-2,5-dione 1a (N-benzyl-3-Boc-aminosuccinimide). Borane dimethylsulfide reduced 3-Boc-aminopyrrolidine-2,5-dione 1a into 3-Boc-aminopyrrolidin-2-one 2a. The same procedure could also be used to prepare derivatives 1 and 2 substituted on the aromatic ring.
Keywords
Cyclic-imide , Aminosuccinimide , Aminopyrrolidinedione , Aminopyrrolidinone
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1841460
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