Author/Authors :
OʹNeil، نويسنده , , Ian A and Ramos، نويسنده , , V.Elena and Ellis، نويسنده , , Gemma L and Cleator، نويسنده , , Ed and Chorlton، نويسنده , , Alan P and Tapolczay، نويسنده , , David J and Kalindjian، نويسنده , , S.Barret، نويسنده ,
Abstract :
Functionalised hydroxylamine derivatives of (S)-prolinol prepared by a Cope elimination have been found to undergo oxidation to the nitrone either in the presence of air or a catalytic quantity of TPAP. These undergo intramolecular cycloaddition to give tricyclic isoxazolidines with high diastereoselectivity.
