One-pot preparation and activation of glycosyl trichloroacetimidates: operationally simple glycosylation induced by combined use of solid-supported, reactivity-opposing reagents

By the combined use of solid-supported reactivity-opposing reagents, that is, basic PTBD and acidic Nafion®-SAC resins, sequential reactions consisting of glycosyl trichloroacetimidate formation and glycosylation can be effected in a one-pot operation starting from 1-O-unprotected sugars. The solid-supported reagents can be introduced into the reaction vessel either sequentially or, more conveniently, in a `one-shotʹ manner in comparable yields.