Title of article
Incorporation of the bioactive moiety of leinamycin into thymidine
Author/Authors
Szilلgyi، نويسنده , , ءkos and Pelyvلs، نويسنده , , Istvلn F. and Majercsik، نويسنده , , Orsolya and Herczegh، نويسنده , , Pلl، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
3
From page
4307
To page
4309
Abstract
A simple synthesis of 1,2-dithiolan-3-ones from α,β-unsaturated thiophenyl esters has been elaborated. With the aim of introducing the biologically active 1,2-dithiolan-3-one-1-oxide moiety of leinamycin into a nucleoside, the method was successfully applied to thymidine-5′-aldehyde.
Keywords
DNA cleaving , Wittig reaction , conjugate addition , ring closure , Leinamycin
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1841789
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