Title of article
An efficient synthesis of novel 1,3-oxazolo[4,5-d]pyridazinones
Author/Authors
Frolov، نويسنده , , Eugene B. and Lakner، نويسنده , , Frederick J. and Khvat، نويسنده , , Alexandre V. and Ivachtchenko، نويسنده , , Alexandre V.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
4693
To page
4696
Abstract
A convenient and versatile synthetic approach to substituted 1,3-oxazolo[4,5-d]pyridazinones is developed. The oxazole ring was formed upon reaction of 5-amino-4-hydroxy-3(2H)-pyridazinone with various carboxylic acid derivatives using a microwave-assisted procedure, which favors the reaction time and purity of the resulting products. The developed methodology is suitable for rapid, parallel, automated synthesis of oxazolopyridazinone libraries.
Keywords
1 , 5-Amino-4-hydroxy-3(2H)-pyridazinone , automated synthesis , Microwave-assisted , Rapid , parallel , 5-d]pyridazinones
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1842061
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