Author/Authors :
Nanduri، نويسنده , , Srinivas and Nyavanandi، نويسنده , , Vijay Kumar and Thunuguntla، نويسنده , , Siva Sanjeeva Rao and Velisoju، نويسنده , , Mahendar and Kasu، نويسنده , , Sridevi and Rajagopal، نويسنده , , Sriram and Kumar، نويسنده , , R.Ajaya and Rajagopalan، نويسنده , , R and Iqbal، نويسنده , , Javed، نويسنده ,
Abstract :
Andrographolide 1, the major constituent of the Indian medicinal plant Andrographis paniculata (Acanthaceae) was converted into the key intermediate 4 by selective oxidative degradation of the C-12,13 olefin bond. The aldehyde functional group present in 4 has been utilized for synthesizing a number of structurally diverse labdane diterpenes. Synthesis and in vitro cytotoxic activity results of the compounds prepared are discussed.
