Author/Authors :
Bergmeier، نويسنده , , Stephen C. and Katz، نويسنده , , Steven J. and Huang، نويسنده , , Junfeng and McPherson، نويسنده , , Howard and Donoghue، نويسنده , , Patrick J. and Reed، نويسنده , , Damon D.، نويسنده ,
Abstract :
We have found that aziridines will react with a variety of π-nucleophiles in intramolecular cyclization reactions to produce nitrogen containing core structures found in a variety of bioactive molecules. These cyclizations are more general and facile than corresponding intermolecular reactions. We have examined the effects of ring size, π-nucleophile identity and substitution on this reaction.
