Enantioselective total synthesis of enokipodins A–D

The first enantioselective total synthesis of enokipodins A–D, highly oxidized α-cuparenone-type sesquiterpenoids with antimicrobial activity, was accomplished by using Meyersʹ diastereoselective alkylation protocol for the construction of the C7-quaternary asymmetric center. The present synthesis also constitutes a formal enantioselective synthesis of (S)-1,4-cuparenediol and (S)-cuparene-1,4-quinone.