Unexpected reaction of 2,2-dihydropolyfluoroalkylaldehydes with ammonia and aldehydes or ketones: a novel synthetic method for 4-fluoroalkyl-1,2-dihydropyrimidine

4-Fluoroalkyl-1,2-dihydropyrimidines were synthesized in good yields by the tri-component reaction of 2,2-dihydropolyfluoroalkylaldehydes, ammonia and aldehydes, ketones or enol ethers in the presence of zinc chloride under mild conditions.