Title of article
Nitrone in l-lyxose series: cycloaddition way for the synthesis of new C-α-fucosides
Author/Authors
Chevrier، نويسنده , , Carine and LeNouen، نويسنده , , Didier and Neuburger، نويسنده , , Markus and Defoin، نويسنده , , Albert and Tarnus، نويسنده , , Céline، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
5363
To page
5366
Abstract
Nitrone 3 analogue of 5-deoxy-l-lyxose was derived from d-ribose. Its reduction with aqueous SO2 gave the corresponding 4-amino-sugar 2, a potent α-l-fucosidase inhibitor. 1,3-Dipolar cycloaddition of 3 with alkenes allowed the synthesis of acetohydroxamic acid and ethane–phosphonate derivatives. Hydroxy-ethane derivative 15 is a nanomolar α-l-fucosidase inhibitor.
Keywords
Phosphonate , nitrone , 1 , 3-Dipolar addition , Amino sugar , Fucosidase inhibitors
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1842348
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