Title of article
A new insight into the Pfitzinger reaction. A facile synthesis of 6-sulfamoylquinoline-4-carboxylic acids
Author/Authors
Ivachtchenko، نويسنده , , Alexandre V and Khvat، نويسنده , , Alexander V and Kobak، نويسنده , , Vladimir V and Kysil، نويسنده , , Volodymir M and Williams، نويسنده , , Caroline T، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
5473
To page
5476
Abstract
The unusual formation of 6-sulfamoylquinoline-4-carboxylic acids from 5-sulfamoylisatins under the conditions of Pfitzinger reaction is described. Key step in the suggested mechanism is the reaction of in situ generated acetaldehyde with the hydrolytically cleaved isatin ring. The suggested mechanism has been confirmed by dynamic LCMS measurements and by reactions with isotopically labeled reactants.
Keywords
Pfitzinger reaction , 5-Sulfamoylisatins , Quinoline-4-carboxylic acids , Acetaldehyde , Ethanol
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1842427
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