Title of article
A convenient scalable one-pot conversion of esters and Weinreb amides to terminal alkynes
Author/Authors
Dickson، نويسنده , , Hamilton D. and Smith، نويسنده , , Stephon C. and Hinkle، نويسنده , , Kevin W.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
3
From page
5597
To page
5599
Abstract
Esters and amides undergo reduction to the corresponding aldehydes using DIBAL-H followed by same pot conversion to terminal alkynes utilizing the Bestmann–Ohira reagent in good to excellent yields. Additionally chiral nonracemic substrates undergo this transformation with complete preservation of stereochemical integrity.
Keywords
Bestmann–Ohira , Seyferth–Gilbert , Alkynes , Weinreb amides
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1842517
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