cis-Carbocuperation of acetylenic sulfoxides and corresponding applications in the regio- and stereoselective synthesis of polysubstituted vinyl sulfoxides

cis-Carbocuperation reaction of monoorganocopper reagent with acetylenic sulfoxides, followed by electrophilic reaction with a variety of electrophiles, provided a regio- and stereoselective method to prepare the versatile polysubstituted vinyl sulfoxides. Sonogashira cross-coupling reaction of the obtained α-iodovinyl sulfoxides with terminal acetylenes was also investigated to afford the versatile conjugate sulfinyl enynes.