Title of article
Direct organocatalytic asymmetric α-hydroxymethylation of ketones and aldehydes
Author/Authors
Casas، نويسنده , , Jesْs and Sundén، نويسنده , , Henrik and Cَrdova، نويسنده , , Armando، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
3
From page
6117
To page
6119
Abstract
Direct organocatalytic asymmetric α-hydroxymethylation of ketones and aldehydes with formaldehyde has been developed, which furnished the corresponding α-hydroxymethylated adducts with high chemo- and enantioselectivity. The reaction is catalyzed by proline derivatives and is a simple method for the enantioselective synthesis of α-hydroxymethylated ketones and aldehydes, and C-2 symmetric diols.
Keywords
?-Hydroxymethylation , organocatalysis , ketones , asymmetric , Aldehydes
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1842879
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