Title of article
Lewis acid deprotection of silyl-protected oligonucleotides and base-sensitive oligonucleotide analogues
Author/Authors
Ferreira، نويسنده , , Fernando and Vasseur، نويسنده , , Jean-Jacques and Morvan، نويسنده , , François، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
6287
To page
6290
Abstract
Oligonucleotides protected with N-(trimethylsilylethoxycarbonyl) (Teoc) and P-(trimethylsilylethanol) (Tse) groups were synthesized and deprotected by a single ZnBr2 treatment. Teoc group stabilized dA against depurination. This strategy was applied to the synthesis of base-sensitive oligonucleotide prodrugs bearing S-acetyl-2-thioethyl (Sate) phosphotriesters.
Keywords
DNA , Silyl protecting group , Teoc , TSE , Sate
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1842947
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