Title of article
Design and synthesis of novel type somatostatin analogs with antiproliferative activities on A431 tumor cells
Author/Authors
Miyazaki، نويسنده , , Anna and Yokoi، نويسنده , , Toshio and Tachibana، نويسنده , , Yoshifumi and Enomoto، نويسنده , , Riyo and Lee، نويسنده , , Eibai and Bokonyi، نويسنده , , Gyongyi and Keri، نويسنده , , Gyorgy and Tsuda، نويسنده , , Yuko and Okada، نويسنده , , Yoshio، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
5
From page
6323
To page
6327
Abstract
It was reported that the somatostatin analog TT-232, d-Phe-c(Cys-Tyr-d-Trp-Lys-Cys)-Thr-NH2, exhibited a highly potent antitumor activity in vitro and in vivo. Using pyrazinone analogs and aliphatic amino acids instead of the disulfide bond, we prepared novel type somatostatin analogs including the sequence essential for antitumor activities, Tyr-d-Trp-Lys. These analogs exhibited antiproliferative effect on A431 tumor cells.
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1842963
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