Author/Authors :
Miyazaki، نويسنده , , Anna and Yokoi، نويسنده , , Toshio and Tachibana، نويسنده , , Yoshifumi and Enomoto، نويسنده , , Riyo and Lee، نويسنده , , Eibai and Bokonyi، نويسنده , , Gyongyi and Keri، نويسنده , , Gyorgy and Tsuda، نويسنده , , Yuko and Okada، نويسنده , , Yoshio، نويسنده ,
Abstract :
It was reported that the somatostatin analog TT-232, d-Phe-c(Cys-Tyr-d-Trp-Lys-Cys)-Thr-NH2, exhibited a highly potent antitumor activity in vitro and in vivo. Using pyrazinone analogs and aliphatic amino acids instead of the disulfide bond, we prepared novel type somatostatin analogs including the sequence essential for antitumor activities, Tyr-d-Trp-Lys. These analogs exhibited antiproliferative effect on A431 tumor cells.
