Author/Authors :
Sheu، نويسنده , , Jyh-Horng and Chao، نويسنده , , Chih-Hua and Wang، نويسنده , , Guey-Horng and Hung، نويسنده , , Kuang-Chih and Duh، نويسنده , , Chang-Yih and Chiang، نويسنده , , M.Y. and Wu، نويسنده , , Yang-Chang and Wu، نويسنده , , Chin-Chung، نويسنده ,
Abstract :
The first A-nor-hippuristanol, A-nor-22-epi-hippurin-2α-carboxylic acid (1), and two 4,5-secosuberosane sesquiterpenoids, isishippuric acids A and B (2 and 3), have been isolated from the gorgonian coral Isis hippuris. Those structures were deduced by extensive 1D and 2D NMR studies. The structure of 1 was further supported by a single crystal X-ray diffraction analysis. Isishippuric acid B has been shown to exhibit potent cytotoxicity toward a limited panel of cancer cells.
Keywords :
A-Nor-22-epi-hippurin-2?-carboxylic acid , Isis hippuris , Isishippuric acid B , Isishippuric acid A , coral
