Title of article
Asymmetric synthesis of α,α-difluoro-β-amino phosphonic acids using sulfinimines
Author/Authors
Rِschenthaler، نويسنده , , Gerd-Volker and Kukhar، نويسنده , , Valery and Barten، نويسنده , , Jan and Gvozdovska، نويسنده , , Natalia and Belik، نويسنده , , Michael and Sorochinsky، نويسنده , , Alexander، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
3
From page
6665
To page
6667
Abstract
Addition of diethyl lithiodifluoromethylphosphonate to enantiopure sulfinimines afforded the corresponding N-sulfinyl α,α-difluoro-β-amino phosphonates with good diastereoselectivity. A two-step deprotection involving treatment of diastereomerically pure N-sulfinyl α,α-difluoro-β-amino phosphonates with trifluoroacetic acid in EtOH followed by refluxing with 10 N HCl afforded enantiopure α,α-difluoro-β-amino phosphonic acids.
Keywords
Fluorine and compounds , asymmetric synthesis , sulfinimines , Diethyl difluoromethylphosphonate , Amino phosphonic acids and derivatives
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1843115
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