Title of article :
Formal total synthesis of camptothecin via ring-closing metathesis strategy
Author/Authors :
Chavan، نويسنده , , Subhash P. and Pasupathy، نويسنده , , Bimal K. and Venkatraman، نويسنده , , M.S. and Kale، نويسنده , , Ramesh R.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Abstract :
A formal total synthesis of camptothecin 1 is presented. The key steps include construction of the D-ring of camptothecin featuring an efficient ring-closing metathesis (RCM) reaction and the subsequent Michael addition of nitropropane across the double bond of the dihydropyridone 3.
Keywords :
Anticancer , camptothecin , ring-closing metathesis (RCM) , Pyridone
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
