Title of article :
Lissoclibadin 1, a novel trimeric sulfur-bridged dopamine derivative, from the tropical ascidian Lissoclinum cf. badium
Author/Authors :
Liu، نويسنده , , Hongwei and Pratasik، نويسنده , , Silvester Benny and Nishikawa، نويسنده , , Teruaki and Shida، نويسنده , , Takeshi and Tachibana، نويسنده , , Kazuo and Fujiwara، نويسنده , , Takeshi and Nagai، نويسنده , , Hiroshi and Kobayashi، نويسنده , , Hisayoshi and Namikoshi، نويسنده , , Michio، نويسنده ,
Abstract :
A novel tribenzotetrathiepin alkaloid, named lissoclibadin 1 (1), has been isolated from the ascidian Lissoclinum sp. (cf. L. badium Monniot and Monniot, 1996). The gross structure was assigned on the basis of the spectral data, and one of two possible isomers was selected by the computational modeling study. Lissoclibadin 1 inhibited the growth of the marine bacterium Ruegeria atlantica (15.2 mm at 20 μg/disk).
Keywords :
Lissoclinum sp. , tunicate , Structure assignment , Polysulfur compound
