Title of article :
Total synthesis and absolute stereochemistry of (9R,10S)-epoxyheptadecan-4,6-diyn-3-one, a diacylglycerol acyltransferase inhibitor from Panax ginseng
Author/Authors :
Oh، نويسنده , , Jung-Hoon and Lee، نويسنده , , Hyun Sun and Rho، نويسنده , , Mun-Chual and Kim، نويسنده , , Young-Kook and Lee، نويسنده , , Hyeong Kyu and Lee، نويسنده , , Woo Song and Kim، نويسنده , , Jae Nyoung and Lee، نويسنده , , Sangku and Jung، نويسنده , , Sang-Hun، نويسنده ,
Abstract :
Asymmetric synthesis of four possible stereoisomers of (9,10)-epoxyheptadecan-4,6-diyn-3-one was accomplished, and the absolute configuration of the naturally occurring (9R,10S)-epoxyheptadecan-4,6-diyn-3-one (1) was elucidated.
Keywords :
absolute configuration , Stereochemistry , asymmetric synthesis , epoxidation , total synthesis
