Title of article
Synthesis of modified Weinreb amides: N-tert-butoxy-N-methylamides as effective acylating agents
Author/Authors
Bernard Labeeuw، نويسنده , , Olivier and Phansavath، نويسنده , , Phannarath and Genêt، نويسنده , , Jean-Pierre، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
7107
To page
7110
Abstract
An efficient preparation of N-methyl-O-tert-butylhydroxylamine hydrochloride has been settled, which allowed the synthesis of modified Weinreb amides. Nucleophilic addition of organolithium and Grignard reagents on these N-tert-butoxy-N-methylamides afforded efficiently the corresponding ketones and reduction with DIBAL furnished the corresponding aldehydes in good yields up to 97%.
Keywords
N-Methyl-O-tert-butylhydroxylamide , acylation , Aldehydes , ketones , Weinreb amides
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1843294
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