Title of article
Site-selective and covalent labelling of the cysteine-containing peptide glutathione with a ferrocenyl group
Author/Authors
Anna and Misterkiewicz، نويسنده , , Boguslaw and Salmain، نويسنده , , Michèle and Jaouen، نويسنده , , Gérard، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
3
From page
7511
To page
7513
Abstract
Site-specific labelling of the cysteine-containing peptide glutathione with a ferrocene group was achieved by reaction with ferrocenylmethanol in aqueous acidic medium. The resulting peptide was shown to be a potent competitive inhibitor of the biologically important enzyme glutathione-(S)-transferase. This approach may prove general for the labelling of proteins with ferrocene.
Keywords
Ferrocene , Labelling , glutathione , Cysteine
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1843436
Link To Document