Development of a new traceless aniline linker for combinatorial solid-phase parallel synthesis of rod-shaped liquid crystals with an azomethine linkage

A new traceless linker was developed to synthesize a library of 28 compounds possessing an azomethine linkage using combinatorial solid-phase parallel synthesis. The loading of the substrates on a solid support and cleavage from the solid support were performed by an imine synthesis and by imine-exchanged process in the mild conditions, respectively. Products with a thioester group exhibited liquid crystalline properties with the higher transition temperatures than the others.