Author/Authors :
Ikemoto، نويسنده , , Tomomi and Nagata، نويسنده , , Toshiaki and Yamano، نويسنده , , Mitsuhisa and Ito، نويسنده , , Tatsuya and Mizuno، نويسنده , , Yukio and Tomimatsu، نويسنده , , Kiminori، نويسنده ,
Abstract :
An asymmetric synthesis of (R)-(+)-6-(1,4-dimethoxy-3-methyl-2-naphthyl)-6-(4-hydroxyphenyl)hexanoic acid 2 as a key intermediate for a neurodegenerative disease agent 1 has been developed. A key reaction was an asymmetric hydrogenation of hindered acrylic acid 13 catalyzed by the Rh-JOSIPHOS system in the presence of a base to afford a chiral acid up to 93% ee.
