Title of article
Combining two-directional synthesis and tandem reactions. Part 4: A concise approach to the spirocyclic core of halichlorine and the pinnaic acids
Author/Authors
Arini، نويسنده , , Louise G. and Szeto، نويسنده , , Peter and Hughes، نويسنده , , David L. and Stockman، نويسنده , , Robert A.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
8371
To page
8374
Abstract
A synthesis of the spirocyclic core structure of halichlorine, an inhibitor of the induced expression of VCAM-1 and the pinnaic acids, inhibitors of PLA2, is presented. A two-directional strategy is employed, in conjunction with a tandem oxime formation/Michael addition/cycloaddition to form the key azaspirocyclic skeleton in a very direct manner.
Keywords
Tandem reaction , cycloaddition , Halichlorine , Two directional , Pinnaic acid
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1843801
Link To Document