Title of article :
Development of silicon-tethered anionic reaction and its application to the synthesis of chiral A-ring moieties of Taxol™
Author/Authors :
Iwamoto، نويسنده , , Mitsuhiro and Miyano، نويسنده , , Masayuki and Utsugi، نويسنده , , Masayuki and Kawada، نويسنده , , Hatsuo and Nakada، نويسنده , , Masahisa، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Abstract :
Silicon-tethered intramolecular nucleophilic additions of a hydroxymethyl unit to ketones in β-hydroxyketones have been developed. The product obtained by this protocol was successfully converted to chiral A-ring moieties of Taxol™. Also developed was a promising silicon-tethered intramolecular α-alkylation reaction of the cyclic hydroxyketone.
Keywords :
Intramolecular reaction , Alkylation , Silicon tethered , nucleophilic addition , Carbanion , Taxol™
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
