Title of article
Kinetic resolution of d,l-myo-inositol derivatives catalyzed by chiral Cu(II) complex
Author/Authors
Matsumura، نويسنده , , Yoshihiro and Maki، نويسنده , , Toshihide and Tsurumaki، نويسنده , , Kazuya and Onomura، نويسنده , , Osamu، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
9131
To page
9134
Abstract
Kinetic resolution of d,l-myo-inositol derivatives having a 1,2-diol functionality by monobenzoylation was achieved using (R,R)-Ph-BOX-Cu(II) as a catalyst. The monobenzoylation preferentially took place at the 1,2-diol functionality via a highly enantiodiscriminatory process, which was largely influenced by a substituent at the position adjacent to the 1,2-diol functionality. This method was applied to a synthesis of biologically important d-inositol-1-phosphate.
Keywords
1 , Myo-inositol , Chiral copper complex , 2-diol , kinetic resolution , Monobenzoylation , Inositol-1-phosphate
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1844097
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