Title of article
α-Hydroxylation of carbonyls using iodine
Author/Authors
Michael J. Zacuto، نويسنده , , Michael J. and Cai، نويسنده , , Dongwei، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
4
From page
447
To page
450
Abstract
The α-hydroxylation of ketones and aldehydes to α-hydroxyketals mediated by iodine under basic conditions in MeOH is described. Enolates generated under the reaction conditions are iodinated and the resulting α-iodocarbonyl is transformed into the hydroxyketal. The use of iodine for this chemistry represents an economical and practical alternative to existing methods for this transformation.
Keywords
Acyloins , ?-hydroxylation , iodine
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1844485
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