Title of article :
An anti-herpes simplex virus-type 1 agent from Xylaria mellisii (BCC 1005)
Author/Authors :
Pattama Pittayakhajonwut، نويسنده , , Pattama and Suvannakad، نويسنده , , Rapheephat and Thienhirun، نويسنده , , Surang and Prabpai، نويسنده , , Samran and Kongsaeree، نويسنده , , Palangpon and Tanticharoen، نويسنده , , Morakot، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2005
Abstract :
A structurally unique polyketide, mellisol (1) and 1,8-dihydroxynaphthol 1-O-α-glucopyranoside (3), were isolated from the fungus Xylaria mellisii (BCC 1005). The relative stereostructure of 1 was determined on the basis of X-ray crystallographic data. Compounds 1 and 3 exhibited activity against herpes simplex virus-type 1 with IC50 values of 10.50 and 8.40 μg/mL, respectively. They also showed cytotoxic activity against vero cells at the concentration of 40–50 μg/mL.
Keywords :
Xylaria mellisii , Mellisol , 8-Dihydroxynaphthol 1-O-?-glucopyranoside , 1 , Anti-HSV-1
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
