Title of article
4,5-Disubstituted cis-pyrrolidinones as inhibitors of 17β-hydroxysteroid dehydrogenase II. Part 1: Synthetic approach
Author/Authors
Cook، نويسنده , , James H. and Barzya، نويسنده , , Jeremy and Brennan، نويسنده , , Catherine H. Lowe، نويسنده , , Derek and Wang، نويسنده , , Yamin and Redman، نويسنده , , Anikَ and Scott، نويسنده , , William J. and Wood، نويسنده , , Jill E.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
4
From page
1525
To page
1528
Abstract
17β-Hydroxysteroid dehydrogenase II (17β-HSD II) antagonists may provide an important way into preventing the onset of osteoporosis. The discovery of 4,5-disubstituted cis-pyrrolidinones as 17β-HSD II inhibitors led to the development of an efficient intramolecular Michael addition, followed by catalytic hydrogenation to obtain the desired cis configuration.
Keywords
Hydroxysteroid dehydrogenase , intramolecular Michael addition , 4 , 5-Disubstituted pyrrolidinones
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1844936
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