Title of article
Approaches to installing a N-gem-dimethylmethylene-2-oxazolyl group and application to the synthesis of a second generation HIV protease inhibitor
Author/Authors
Ikemoto، نويسنده , , Norihiro and Miller، نويسنده , , Ross A. and Fleitz، نويسنده , , Fred J. and Liu، نويسنده , , Jinchu and Petrillo، نويسنده , , Daniel E. and Leone، نويسنده , , Joseph F. and Laquidara، نويسنده , , Joseph and Marcune، نويسنده , , Benjamin and Karady، نويسنده , , Sandor and Armstrong III، نويسنده , , Joseph D. and Volante، نويسنده , , Ralph P.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
5
From page
1867
To page
1871
Abstract
Two syntheses of the title compound 1 were developed based on different approaches for installing the oxazole ring moiety. Formation and dehydration of ketoamide was initially used and scaled up to afford 1 on several kilogram scale, then oxazolyl anion/iminium coupling reaction was developed for a more convergent approach.
Keywords
Oxazole , Epoxide opening , protease inhibitor , Piperazine
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1845082
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