Title of article
Large scale Biginelli reaction via water-based biphasic media: a green chemistry strategy
Author/Authors
Bose، نويسنده , , Ajay K. and Manhas، نويسنده , , Maghar S. and Pednekar، نويسنده , , Suhas and Ganguly، نويسنده , , Subhendu N. and Dang، نويسنده , , Hoang and He، نويسنده , , William and Mandadi، نويسنده , , Arun، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
3
From page
1901
To page
1903
Abstract
An important stage in process development is kilo scale preparation of the target compound. For this reason, a procedure involving water-based biphasic reaction media has been developed for conducting some exothermic reactions on a large scale. This protocol is illustrated by the energy-efficient and rapid preparation of dihydropyrimidinones by a solvent-free, green chemistry procedure applied to the Biginelli reaction using p-toluenesulfonic acid as catalyst.
Keywords
Biginelli reaction , Biphasic media , p-TSA as catalyst , Dihydropyrimidinones
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1845096
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